02x02 - Worth the Risk

[bunniefuu]

[TENSE MUSIC]

I read this piece in "The Times"

about this little girl

who needs a new windpipe.

Name's Hannah Warren.

Her family's working with

this doctor in Europe.

Dr. Paolo Macchiarini.

The focus of my research

is tracheal transplants

with the help of stem cells

by developing biosynthetic tracheas.

So you're basically tricking the body

into thinking the implant's

already a part of you.

Will you be interested in assisting?

Yes. Yes.

I was wondering if

you would be interested

in collaborating on rat

trials to test our tracheas.

- Absolutely.

- Welcome to the team.

So this is the first artificial-trachea

transplant in the U.S.,

and I want Hannah's journey

to be the focus of the piece.

Surgery went well.

I have watched you for a while now.

What you did, it was a miracle.

- [CHUCKLES]

- Paolo, I shouldn't.

The science doesn't seem sound.

It's not exactly your kind of science.

I will admit I don't get it.

Kn*fe.

After the operation,

she's healthy and happy

with her donor trachea.

[PERSON COUGHING]

[FOREBODING MUSIC]

[COUGHING CONTINUES]

♪

[MONITOR BEEPING]

♪

[NO AUDIO]

♪

[MONITOR FLATLINING]

♪

[ALARM BLARING]

Hannah Warren will be

the youngest patient

ever to receive a biosynthetic

tracheal transplant.

Okay, stop right there.

Let's swap this out to play

over Dr. Macchiarini talking

about the initial diagnosis.

[SIGHS] I think we still

need a little more B-roll

with the parents, but

we are close to locking.

Ow.

- You okay?

- Yeah, I'm okay.

[EXHALES DEEPLY] [CELL PHONE VIBRATING]

Hi.

I was just talking about you.

Uh, Benita.

Daryl?

I called to, um

I called to tell you she, uh

she's gone.

- [DOOR CLOSES]

- What?

Hannah's gone.

What what do you mean she's gone?

It was There were complications.

Her her lungs, after all

the time in the hospital,

she just her body couldn't, um

Hannah's gone.

We were with her, and she

just kept getting worse.

We thought maybe she was gonna

that it would pass, but, uh

[CONTINUES INDISTINCTLY, VOICE FADES]

♪

[CELL PHONE VIBRATING]

Mom, your phone.

[VIBRATING CONTINUES]

[PHONE CLATTERS LIGHTLY]

- Is it work?

- No, it's not work.

What's up with the braids, kiddo?

I haven't seen you

repeat a hairstyle twice,

let alone three times, in a week.

Dad liked my hair this way.

I miss him, too.

But I think you look great.

You ready for school?

[CELL PHONE VIBRATING]

What are you doing here?

I wanted to make sure that you're okay.

You're not answering my

phone calls, my texts.

You shouldn't be here.

I know you heard about Hannah.

I just wanted to make sure

that you're okay, Benita.

I thought she was getting better.

- There were complications.

- "Complications.

"Fragile native tissue.

Weakening of the lungs."

I-I read the reports,

Paolo. I know the medicine.

But you told me she was getting better.

She was very sick.

And she was going to die.

I tried.

You think that I'm not upset?

But I won't give up.

I don't have the right to give up.

No, Paolo, don't. I-I can't do this.

Let's just call it what it is, okay?

What is it?

A mistake.

Colleagues, board members,

we are so glad to have you here

for this momentous occasion.

Tomorrow we will perform the

first-ever human transplant

using a bioartificial scaffold.

Our patient is Andemariam Beyene,

a 36-year-old Eritrean PhD

student living in Iceland.

Two years ago, he developed a

malignant tumor in his windpipe.

They have tried radiation

and surgical intervention.

All failed.

So his doctors referred him to us.

As you all know, we only have approval

to perform this procedure

as compassionate use,

a last resort.

We have designed a biosynthetic trachea

tailor-made to Mr. Beyene's anatomy,

down to the last micrometer.

And this truly is the breakthrough

that will launch us

as a global destination

for this kind of medicine.

Ladies and gentlemen,

I present to you the future

of regenerative medicine.

[DRAMATIC MUSIC]

Within weeks, it will grow tissue,

transforming into an

actual, living trachea.

♪

[COUGHS]

Dr. Macchiarini, I am sorry.

I no longer wish to have the surgery.

We feel it is too risky.

It is completely natural to

have concerns, Mr. Beyene.

The trachea, it's plastic.

How can you be sure it

will work inside my body?

There you misunderstand.

It is not plastic.

The trachea is medical-grade

polymeric nano-composite material.

- If I may.

- Yeah, of course.

Mr. Beyene, you're studying

lava tubes in Iceland.

- Is that right?

- Yes.

I believe the recellularization

process is just like that.

When a volcano erupts,

underground lava rivers create tubes.

When the lava drains, the tubes remain,

but now they're rock solid.

They become a part of the Earth.

And that means they last forever.

That's what your stem cells

will do to the synthetic trachea

to make it last forever

as a part of you.

You're asking my husband to be the first

but offer no guarantee

the procedure will work.

No, we cannot offer guarantees

because it would be

irresponsible to do so.

Nothing is guaranteed in medicine.

Even just a year ago,

your options would have

been much more limited.

You are very lucky to be the first.

Your doctors referred you to us

because the other treatments failed you.

You could have as little

as six months to live.

This is your best chance

to see your son grow up.

♪

Okay.

Okay.

I think it's very difficult

to keep an emotional distance,

especially if it is a child.

- Hey.

- [KEY CLACKS]

How you holding up?

I wish I felt numb.

I just feel

everything.

Give yourself a break, B.

- You're not on a schedule here.

- [SIGHS]

It's gonna take what it takes.

You know, with Hannah Warren and John

it's just a whole lot of death.

How's Lizzi?

She's really quiet.

I think she's pretending

to be okay for me,

which makes me feel guilty,

which makes me feel worse.

She's just such a daddy's girl.

And that breaks my heart.

At least you still

have a heart to break.

Yeah, the pain reminds us we're alive.

It's awesome.

- Work is good?

- Work is good.

Work is good.

Hey, how's that piece coming along?

Hey, it's not.

It's

a special about the future of medicine.

It's supposed to be hopeful.

And now I don't have a story at all.

- What about him?

- What about him?

Shift the focus to him, you know?

"Dr. Macchiarini, Miracle Man"

a look at the pioneer

of generational medicine.

- Regenerative.

- Exactly.

But then what about Hannah?

She'd still be part of the main story.

Medical breakthroughs are

always paved with setbacks.

It doesn't mean that Macchiarini's work

isn't worth believing in.

♪

Hold on to the hopeful.

If anybody can make it happen, it's you.

♪

[NO AUDIO]

[TRAIN RUMBLING]

- [INDISTINCT CHATTER]

- When did the pain start?

Um, off and on for the last few weeks.

I just thought it was

stress or something.

Would you describe the pain

as sharp, dull, or burning?

Sharp, like Aah! [WINCES]

Like someone's stabbing me. Ow.

Let's get a CBC, liver enzymes,

urine test, and a CT of

the abdomen and pelvis,

plus 30 milligrams of

Toradol for the pain.

- So it's my appendix?

- It's not your appendix.

What? No, no, no, no, no.

I have a daughter. She's nine years old.

She just lost her father.

I can't have something wrong with me.

We just need to run some

tests to see what's going on.

Doctor, they're waiting.

Is there anyone you want to call?

[SIGHS]

[INDISTINCT ANNOUNCEMENT OVER PA]

Hi, excuse me.

- Hi.

- Hi.

Thank you for coming. I'm sorry.

No, no, I'm glad you called.

- Has the pain subsided?

- No.

I think it's worse, actually.

- What did the doctor say?

- Nothing.

They just ran a bunch of tests,

and no one's told me anything.

I've just been sitting here by myself.

You CT scan shows uterine fibroids.

What? What is that? Is that cancer?

Not at all. They're very common.

- Is it okay if I take a look?

- Yeah.

- Yeah?

- Okay.

[SIGHS]

- This might hurt a little bit.

- Okay. All right.

- Okay.

- [MONITOR BEEPING]

- [GROANS]

- Yeah, I can feel two.

They're about the size of grapefruits.

What?

It sounds much worse than what it is.

Don't worry. They

will have them removed.

So I have to have surgery?

Yeah, but it's a very common procedure.

I'm sure your doctor will

walk you through everything.

You're gonna be fine.

Trust me.

♪

He's got you working late already?

I'm preparing.

It's something doctors do.

- You should try it.

- Noted.

I'll sleep when I'm published.

[SIGHS]

Why don't you like him?

I don't really like anybody.

That's true.

Still, so few surgeons want to

operate on the throat at all,

and he throws in stem-cell regeneration.

Aren't you interested in his work?

Yes, yes, I find it all very

interesting.

You're an ass.

Look at this.

He has to identify the surgical

planes bordering the trachea,

avoid tumor dissemination,

all without exposing the larynx,

the thyroid, the esophagus.

Say what you want.

Dr. Macchiarini's got some balls.

I guess that's what it takes,

huh some nice big balls?

Sorry, I didn't mean to offend you.

Yes, I have tiny balls.

[INHALES DEEPLY]

You know, a good surgeon

knows when not to cut.

f*ck that. I'm tired of being

on the verge of something.

Too afraid to make the cut

this is groundbreaking work.

I'm getting in.

Just watch your back.

I always do.

♪

[DEVICE BEEPING]

[RAZOR WHIRRING]

♪

Dr. Svensson.

Dr. Macchiarini? Uh

- [SPEAKING NATIVE LANGUAGE]

- [SPEAKING NATIVE LANGUAGE]

Oh, the trials seem to

be proceeding nicely.

Uh, yes.

Um, we're on schedule.

Good.

Any exciting conclusions so far?

Well, nothing you know,

nothing really determinable yet.

Of course, I won't be

able to truly discern

any results until

Yeah, until you completed

the trials, of course.

As you can imagine,

I'm I'm very anxious

to see any results

positive or otherwise.

Well, on the test rats that

have received synthetic tracheas,

so far none have responded negatively.

Well, that that is excellent.

But as you said, we're

still gathering data.

Uh

the purpose of this trial

is to witness objective

results, of course.

Of course, of course.

May I ask, is there

anything in particular

- that is concerning you?

- Oh, no, not at all.

I have complete faith

in your research, Doctor,

as well as my own.

I'll just leave you to your work.

Okay.

Yeah.

♪

[DISTANT SIREN WAILING]

- Thank you.

- Yeah, no problem.

Oh, thank you, thank you, thank you.

Oh, my God, please.

Wow, I wish I had that effect on you.

48 hours without caffeine?

Who am I today?

I spelled your name for them.

[DISTANT SIREN WAILING]

- You're feeling better?

- Mm-hmm.

I am. Like two grapefruits lighter.

Thank you, really.

Pleasure.

Paolo

we've both been through a lot

of loss the past few months.

And I know I wasn't

dying in there, but I

I was really scared, and it

[DRAMATIC MUSIC]

It just

it put things in perspective for me.

Us together, it could cost

me my job, my reputation,

but I think this thing we

have, it's worth the risk.

[DISTANT SIREN WAILING]

For me, too.

♪

You've heard the criticism

that you're really taking a

chance with these patients.

What do you say to that?

I was raised to believe that if you

if have even one chance,

you need to take it,

because either that patient will die,

or we try to do something,

even if it's new.

As a doctor and and

as a human being, I

I ask myself, are we allowed to say no?

I don't think we are.

And when you got that call later

- that that she had passed

- Mm.

It had to be devastating for you.

I couldn't stop thinking

did I make the right decision?

Did I do everything to save her?

There are so many patients

all around the world

who need this procedure.

We should really try to achieve this

for all of them,

because even in the face of failure,

we should keep hope alive.

♪

Great job today, guys.

Dr. Macchiarini, do

you mind staying behind

for a few minutes to

go over the schedule?

Good night.

♪

Of course.

So?

So

Well, I have some

follow-up questions for you

that are gonna happen

- Really?

- Behind closed doors, yeah.

I'm so sorry you had to go through this.

It's okay.

It's just gonna be a scar.

One day we will live in a world

where we won't have to cut

people open to fix them.

You'll see.

Do you ever have any doubts?

Of course I do.

- Really?

- Mm-hmm.

'Cause you seem so sure of all of it.

Even the things that could go wrong,

that have gone wrong

you just keep moving forward.

I think a lot about the

ones who came before me.

Like Thomas Starzl

he started the first liver transplants.

- His first patients d*ed.

- Hmm.

Or Christiaan Barnard

he performed the first heart transplant.

People threw rocks at him.

- Everybody thought he was crazy.

- [SCOFFS]

I'm sure people looked

at him the same way

that you're looking at me right now.

[CHUCKLES]

♪

When Hannah d*ed, I did lose faith.

But these doctors, they

they believed, they

worked, they persevered

until they found their way.

Being the one to try something new,

no matter the personal cost,

is vital to move medicine forward.

It's vital.

And I believe that the

work that we're doing

is going to save many lives.

I believe it will, too.

♪

Hi, my love. I'm here,

missing you in Barcelona.

The lemon trees are ready for you.

Oh, there is a sushi

roll with my name on it.

- Benita?

- Hmm? Oh, yeah, lunch.

- You ready?

- Sorry. Yeah.

Good.

[DRAMATIC CLASSICAL MUSIC]

♪

[BENITA LAUGH]

♪

- Mm.

- Come on, come on

♪

No, I hear you. The

information is great.

But I'm going to need

another source on it

to confirm her account.

Sure. Could you email that to me?

Wow, that sounds good.

Yeah.

- [WHISPERING] It's Lizzi. Okay.

- [WHISPERING] I'll miss you.

Yeah. Sure.

It's okay with me.

If it's okay with Aubrey's

mom, you can sleep over.

Okay. I love you, too. Bye.

- Did you say "sleep over"?

- Yeah.

Maybe I could change my flight.

Oh, I didn't know that was an option.

Mm-hmm.

♪

- What?

- The Stones are sexier.

- No, no, no.

- That's it.

How can you even compare them?

I've always thought this, and

I'm not going to apologize.

"Blackbird," um

- [LAUGHS]

- "Martha My Dear,"

"While My Guitar Gently

Weeps," "Rocky Raccoon."

Okay, now we're listing songs?

- Yeah.

- "Satisfaction"

- Oh.

- "Gimme Shelter,"

- "Sympathy for the Devil."

- No.

No, we can't have this conversation.

This is terrible. Now

I have to leave you.

- Are you gonna leave me?

- I'm gonna leave you.

Are you gonna leave me for The Beatles?

- This is a very, very

- They're almost

- All of them are dead, almost.

- Important distinction.

[BOTH LAUGH]

[DOORBELL RINGING]

Italian "Vogue," nice touch.

- For Lizzi.

- Ah.

Hey, Lizzi? My friend Paolo is here.

- Your "friend"?

- My friend.

[SOFT MUSIC PLAYING]

♪

"Cacio" means "cheese,"

and "pepe" means "pepper."

So it's like Italian mac and cheese.

[PHONE VIBRATING, BENITA CHUCKLES]

And pepper, you know, "pepe."

It's delicious, right?

What do you think, kiddo?

I don't like it.

♪

Your mom tells me that

you play the violin.

- She does, yeah.

- Yeah?

She practices every day.

Sometimes I don't even

have to ask her to practice.

Oh, wow. That's impressive.

It's impressive,

'cause I used to play the

piano when I was your age,

- but I hated to practice.

- [BENITA CHUCKLES]

Well, maybe we can play together.

You you play the violin,

and I play the piano.

We make a concert for your mom.

♪

Mm.

Did you hear what happened

when Johann Sebastian Bach

dropped his violin?

It Baroque.

It Ba-roque.

Ba-roque, that's funny.

- Can I go to my room?

- Lizzi, come on, please.

- No, it's okay.

- [BENITA STAMMERS]

But, Lizzi

I know that you're feeling

a thousand things right now,

all at once.

And I'm ready to wait

for as long as it takes

for you to figure out

how you feel about me.

But I'll make you a deal.

If you let me show you

how much I care about your mom,

I promise you I will never make you eat

my cacio e pepe again.

Accordo?

♪

Accordo.

♪

Good night.

[CLEARS THROAT] [DOOR CLOSES]

- [CHUCKLES]

- She'll get there.

It takes time.

♪

It's really good.

But you got it, right, Baroque?

- I got Baroque.

- Okay.

Yeah, it's a cute joke.

♪

Hey, three more pages, then

jammies and lights out, okay?

Okay.

♪

- I love you.

- I love you, too.

Good night.

Hey, Mom?

♪

I like his accent.

♪

[PAOLO SPEAKING RUSSIAN]

What? Are you kidding me? You cooked.

Get out of here.

[SPEAKING RUSSIAN]

What?

I have bad news.

Our trip to Barcelona No!

- I have to cancel.

- Oh.

Uh, there's there's a new patient

I need to meet in Moscow.

I was so looking forward to

finally seeing your place.

I know, my love, and I'm so sorry,

but if she agrees to surgery,

this could launch funding

for the entire lab.

No, I-I get it, I get it.

I just, um

have to figure out what to

tell Kim and everybody else,

'cause I already took time off.

And I have Laura coming

to stay with Lizzi and

Why don't you come with me?

- To Russia?

- To Moscow.

I can show you off in Moscow.

I don't know. [CHUCKLES]

Oh, come on, Benita, I

want to spend time with you

without having to hide please.

We have to wait until the special airs

before we tell anybody anything.

I'm sure our secret

will be safe in Russia.

Please come with me.

- Please, come with me.

- Okay.

I mean, who

who am I to say no to

the great Dr. Macchiarini.

♪

[DEVICE BEEPING]

[MONITOR BEEPING]

Accessing the cricoid ring.

[DRAMATIC MUSIC]

♪

I see severe infection,

most likely caused

by the excessive radiation

treatments on the patient.

The cartilage is necrotic.

If the tumor hadn't k*lled him,

it would have been only a matter of time

before he succumbed to infection.

♪

Kn*fe.

♪

Starting resection.

The biosynthetic trachea will fit

perfectly in the resected area.

♪

[DEVICE BEEPING]

[MONITOR BEEPING]

♪

Metzenbaum.

♪

[SCISSORS SNIPPING]

♪

Okay.

♪

Okay, switch the oxygen input.

♪

Saline.

Any leaks in the trachea will

produce bubbles in the saline.

♪

Pulse ox?

Holding steady.

♪

No signs of leaking.

Oxygen holding, 98%.

It's working.

Congratulations, Doctor.

Okay, let's close him up.

- [ALARM BLARING]

- Doctor?

BP's dropping.

- He's bleeding.

- Vitals are weakening.

No, it can't be. The implant is working.

Where is this blood coming from?

- [BLARING CONTINUES]

- Doctor?

The left carotid's most likely ruptured.

No, I didn't touch it.

I wasn't even near it.

You said there was radiation damage.

Losing OX.

It must have weakened the vascular wall.

- Doctor.

- Blood pressure is dropping.

Doctor, we need to do something.

- Doctor?

- Losing oxygen.

Doctor?

Paolo!

I can fix this.

He needs to be stabilized.

[BEEPING AND BLARING CONTINUE]

- Suction?

- Blood pressure is dropping.

♪

Found it. Cautery.

[BEEPING AND BLARING CONTINUE]

♪

- [MONITOR BEEPING]

- BP is on the rise.

He's stable.

Sutures for Dr. Macchiarini.

You should close him.

[DOOR CLOSES]

[INDISTINCT CHATTER]

[DRAMATIC CLASSICAL MUSIC]

♪

- [SPEAKING RUSSIAN]

- [SPEAKING RUSSIAN]

- [SPEAKING RUSSIAN]

- [SPEAKING RUSSIAN]

All right, my love, this way.

I was texting with Lizzi about

setting up our Skype call.

Mm-hmm?

And she specifically

asked for you to jump on.

- Oh, she did?

- Yeah.

You charmed her, you big charmer.

[LAUGHS]

[SPEAKING RUSSIAN]

Pardon me.

Uh, compliments of the

gentleman at the bar.

♪

Thank you.

[CHUCKLES]

To you, to me, and to

ice buckets, always.

[CHUCKLES] Cheers.

So who is our benefactor this evening?

- I shouldn't say.

- Paolo, come on.

I protect sources for a living.

He's a Russian oligarch, very connected.

No, don't look.

There is a network of

high-profile patients,

celebrities, clergy, presidents

that are treated in secret,

that I treat in secret.

Because of who they are,

I have to keep our arrangement quiet.

Presidents, like U.S. presidents?

[CLEARS THROAT]

Paolo Macchiarini, surgeon to the stars?

- [CHUCKLES]

- Okay.

I Somebody's got to do it, right?

- Shh, they're coming.

- Oh. [CLEARS THROAT]

Yulia, this is Benita Alexander.

- Paolo, good to see you.

- It's nice to meet you.

[BENITA CHUCKLES]

[CHUCKLES] If you're trying

to impress me, Doctor,

it's it's working.

Yulia, my dear, for you, only the best.

Uh, Paolo tells me you're a dancer.

- The best in Russia.

- [SCOFFS]

I met Andrej not long

after I joined the Bolshoi.

I saw her perform in "Swan Lake."

She was magnificent.

I was only part of the corps

de ballet, not the soloist.

Still, I could not

take my eyes off of her.

[BOTH LAUGH]

While I was on tour in

London a few years ago,

I was involved in a

horrible car accident.

It's a miracle she's even alive.

My windpipe was broken. My

Everything was broken.

And it left me with

this hole in my neck.

I'm so sorry.

The past is a lighthouse, not a port.

[CHUCKLES] I found Dr. Macchiarini.

Up until now, we have implanted

only patients for compassionate use,

those who otherwise would die.

But you have shown me

that quality of life

is nearly as important as life itself.

So this is an elective surgery?

- Yeah.

- Mm.

A part of me

hopes it will allow me to

dance again, but, mostly

we have a two-year-old son, Sasha.

I want to play with him [CHUCKLES]

Sing him a lullaby.

And you're the perfect candidate.

You're young, healthy,

no other medical issues that

would complicate matters.

You you're ready.

Mm. I really don't want to go to Sweden.

I wish you were set up

to operate in Russia.

Then I have great news for you.

Our colleague, Dr. Lasbrey,

is setting up facilities

in Krasnodar as we speak.

Your procedure will launch

our work here in Russia, Yulia.

You will have your operation here.

[CHUCKLES]

[CHUCKLES]

- To Dr. Paolo Macchiarini

- Ah.

Our rock-star surgeon.

[ALL SPEAKING RUSSIAN]

[DRAMATIC MUSIC]

Mm.

- You okay?

- Mm-hmm.

- Yeah?

- Yeah, I'm okay.

♪

[SIGNAL CHIMING]

This ballet was first performed in 1871.

You know

Are you okay?

- [GROANS]

- Hey. Hey, hey, hey, my love.

- [WINCING]

- Hey, are you okay?

I'm sorry. I don't think I can

No, no, no, we'll go home.

No, we'll go. I text you.

No, she's I'll text you, okay?

- Let's go.

- Are you sure? Should I

Yes. Yeah, yeah.

♪

You're getting worse.

You should have let me

take you to the hospital.

No, I just want to lie down.

[GROANING]

- You're burning up.

- Mm. I feel sick.

Let me check something.

The surgical site is infected.

What? There's no way.

That was months ago.

- It's got to be healed by now.

- No, it's not.

[GROANING]

♪

So so what, antibiotics or something?

No, it's too late for that.

You're in sepsis. I need

to debride your wound.

Otherwise, you will go into shock.

"Debride"? What does that mean?

- You're gonna be okay.

- [GROANS]

[BREATHING HEAVILY]

Do you trust me?

♪

Mm-hmm.

♪

[BREATHING HEAVILY]

[GROANING]

♪

[GROANS LOUDLY, BREATHING HEAVILY]

[GRUNTS, SCREAMS]

[APPLAUSE]

"Two months after transplantation,

the patient is asymptomatic,

breathes normally, and is tumor free.

These results are evidence

that a successful

organ-regeneration strategy

has been accomplished."

[LAUGHS] "And the procedure's

success provides proof

of the viability of this approach."

[CHEERS AND APPLAUSE]

To Dr. Macchiarini, who

dared to make the cut.

Cheers.

To Andemariam Beyene,

who bravely risked his life for science.

Cheers.

And last but not least,

to The m*therf*cking "Lancet"

for publishing our research article.

- Cheers!

- Skol, Anders.

Nathan, tack.

So published in "The Lancet"

you're halfway to a Nobel.

This is sh*t.

You'd think they would have

sprung for better bubbly.

Then feel free to steal someone else's.

- Fantastic.

- Cheers.

I'm surprised to see you here,

knowing how you feel

about Dr. Macchiarini.

Well, free champagne

is free champagne

- or whatever this is.

- Of course.

You must all be on cloud nine.

I'm excited, of course,

though I also have the feeling of

What do you call it?

Impostor's syndrome.

Why?

You're running Macchiarini's rat trials.

Which are still in progress.

Macchiarini included

my name in the byline,

but I have yet to submit my results.

Welcome to the world of

scientific publishing.

As I recall someone once saying,

"Competition fuels progress."

[CHUCKLES]

[INDISTINCT CHATTER]

[DRAMATIC MUSIC]

♪

- Okay.

- Here we go.

Watch out for the chair.

[LAUGHING] Yeah, but

I can't watch anything.

Okay.

- Okay, you can open your eyes.

- No.

You said you wanted

to start playing again.

- We can do a duet.

- Wow.

Yeah, we can do a duet.

This is incredible. Thank you.

- Careful with your stitches.

- Aw.

Love, come here.

Thank you so much. [SMOOCHES]

Wow, this is so cool.

But first, I have to

remember how to play.

- Oh, let me get my phone.

- This is so cool.

Thank you.

[PLAYING CHOPIN'S

"NOCTURNE OP. 9, NO. 2"]

[LAUGHS]

♪

[BENITA CHUCKLES]

♪

Knowing I'll be missing ♪

Christmas Eve in my hometown ♪

- Thank you.

- Mm.

Are you okay?

Yeah. Christmas, family

holidays, you know?

It makes you sad?

Not really, not this year.

We feel like a family.

You read my mind.

Lizzi.

[BREATHES EXCITEDLY]

Wait. Hold on.

What what is going on?

This feels like collusion.

♪

Through dreams and just pretending ♪

I'm there, and I'll be spending ♪

Christmas Eve in my hometown ♪

What do you say, Mom?

What do you say?

In my hometown ♪

[LAUGHTER]

♪

[DEVICE WHIRRING]

- Hey, come in.

- Hello.

Hi. Please come in.

Look

Mr. Beyene sent it.

Oh.

[INDISTINCT CHATTER ON CELL PHONE]

- It's nice, isn't it?

- Yeah.

I wish our work always ended like that.

Yes.

Thank you for sharing that with me.

Sometimes it's nice to

be reminded why we

Sacrifice.

So you, too?

Oh, you know, nothing big

just girlfriends, children,

probably a few years off my life.

Well, maybe we can

build something together

that will make it all worthwhile.

I think we can.

The funding for our transplant

research is about to run out.

I'm sure "The Lancet" article

garnered some attention.

Yes, we can capitalize on that

momentum to secure a new grant,

which will lead to more surgeries

and to more money.

Around and around.

Until we can expand

globally.

The goal is six operations

within the next three months.

[DRAMATIC MUSIC]

You can produce that many

custom tracheas in that time?

Yes, it can be done.

But we need more patients.

Then let's find more patients.

♪